PCSK6 CLIA Kit for Human(Homo sapiens) | EIAab.comPCSK6 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > PCSK6(Gene name) > Human

PCSK6 (Gene name),

Proprotein convertase subtilisin/kexin type 6 (Protein name ), PCSK6_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PCSK6(PACE4);

Protein name:

Proprotein convertase subtilisin/kexin type 6;

Alternative:

Subtilisin-like proprotein convertase 4(SPC4);Paired basic amino acid cleaving enzyme 4;Subtilisin/kexin-like protease PACE4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The PACE4A-I precursor protein seems to exist in the reticulum endoplasmic as both a monomer and a dimer-sized complex whereas mature PACE4A-I exists only as a monomer, suggesting that propeptide cleavage affects its tertiary or quaternary structure.

Function:

Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif.

Subcellular Location:

Isoform PACE4B Secreted

Protein Attributes:

Sequence length:

969

Sequence:

50:

100:

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200:

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650:

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950:

969:

LCERKLFIQF | CCRTCLLAG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P29122

MIM:

167405

KEGG:

hsa:5046

UniGene:

Hs.498494

String:

P29122

Pfam:

PF01483

Uniprot:

P29122

FOR

ELISA Kit for Human Proprotein convertase subtilisin/kexin type 6

Cat.:

E10825h

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Packing:

96T

ELISA Kit for Human Proprotein convertase subtilisin/kexin type 6

Cat.:

E10825r

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Packing:

96T

CLIA Kit for Human Proprotein convertase subtilisin/kexin type 6

Cat.:

U10825h

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MSDS:

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Packing:

96T

CLIA Kit for Human Proprotein convertase subtilisin/kexin type 6

Cat.:

U10825r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Proprotein convertase subtilisin/kexin type 6

Cat.:

P10825Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Proprotein convertase subtilisin/kexin type 6

Cat.:

P10825Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Proprotein convertase subtilisin/kexin type 6

Protein for Human Proprotein convertase subtilisin/kexin type 6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15."
Kiefer M.C. , Tucker J.E. , Joh R. , Landsberg K.E. , Saltman D. , Barr P.J.
DNA Cell Biol.10:757-769(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PACE4A-I AND PACE4B)
tissue: Hepatoma.
tissue: Kidney.
2.

"Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms."
Tsuji A. , Higashine K. , Hine C. , Mori K. , Tamai Y. , Nagamune H. , Matsuda Y.
Biochem. Biophys. Res. Commun.200:943-950(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PACE4C AND PACE4D)
tissue: Placenta.
3.

Tsuji A. , Higashine K. , Hine C. , Mori K. , Tamai Y. , Nagamune H. , Matsuda Y.
Biochem. Biophys. Res. Commun.204:1381-1382(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Identification of a novel PACE4 isoform, PACE4E."
Mori K. , Imamaki A. , Kii S. , Nagamune H. , Nagahama M. , Tsuji A. , Matsuda Y.
Submitted (1996-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM PACE4A-II)
tissue: Placenta.
5.

"A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus."
Mori K. , Kii S. , Tsuji A. , Nagahama M. , Imamaki A. , Hayashi K. , Akamatsu T. , Nagamune H. , Matsuda Y.
J. Biochem.121:941-948(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PACE4E-I AND PACE4E-II)
tissue: Cerebellum.
6.

"Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease."
Tsuji A. , Hine C. , Tamai Y. , Yonemoto K. , Mori K. , Yoshida S. , Bando M. , Sakai E. , Mori K. , Akamatsu T. , Matsuda Y.
J. Biochem.122:438-452(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS PACE4A-I; PACE4A-II; PACE4CS; PACE4D; PACE4E-I AND PACE4E-II)
7.

"Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform."
Zhong M. , Benjannet S. , Lazure C. , Munzer S. , Seidah N.G.
FEBS Lett.396:31-36(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM PACE4CS)
8.

"Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain."
Sucic J.F. , Moehring J.M. , Inocencio N.M. , Luchini J.W. , Moehring T.J.
Biochem. J.339:639-647(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
9.

"Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4)."
Nagahama M. , Taniguchi T. , Hashimoto E. , Imamaki A. , Mori K. , Tsuji A. , Matsuda Y.
FEBS Lett.434:155-159(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING

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